Bristol-Myers Squibb Symposium-NOTE EVENT, TIME & LOCATION CHANGES

Anion Relay Chemistry (ARC), an effective multi-component union protocol recently developed and employed in our laboratory holds great potential for chemists requiring rapid increase of molecular complexity in a single operation with precise control of stereogenicity en route to both natural and natural product-like targets for biomedical research. Employing this technique, a large number of diverse structures can be rapidly assembled from a small number of initiating nucleophiles, bifunctional linchpins, and electrophiles in a controlled, multi-component coupling reaction. Recent efforts to expand the scope of this tactic to include the construction of natural products, as well as libraries of "natural product-like compounds, highlight the robust nature of this protocol. The evolution of this tactic, involving both Type I and Type II ARC tactics will be presented with illustrations arising from alkaloid and polyketide/macrolide total synthetic ventures currently ongoing in our laboratory.