CCHF Virtual Merck Lecture Series

     Large arrays of rationally designed experiments are a powerful tool for solving complex and challenging chemical problems.  In this lecture, conceptual and practical aspects of high-throughput experimentation will be presented, followed by recent examples of high-throughput experimentation-enabled reaction discovery, development and mechanistic elucidation applied to asymmetric hydrogenation with first-row transition metals.  Participants will gain an understanding of the strengths and limitations of running large arrays of experiments and an appreciation for the wealth of tools that can be employed to solve their chemistry problems.