CNS Seminar

Distinct interneuronal subtypes deliver GABA to specific spatial domains of principal cells at particular times during behaviorally relevant network oscillations in cortical circuits. Recent results from awake mice have revealed emerging novel principles of the temporal ordering of interneuronal discharges during network oscillations in the hippocampus. I will discuss new evidence showing the highly non-homogeneous organization of inhibitory-excitatory microcircuits in the hippocampus with major implications for information processing. Next, new insights into cell type-specific control of hippocampal spatial memory functions will be addressed. Finally, I will discuss results from data-driven, full-scale (1:1) computational models of the hippocampus that give us quantitative insights into the roles of the various constituent cell types in ensemble network activities.