General Biology Seminar

Naturally occurring proteins beautifully solve the challenges that arose during natural evolution.  Computational design holds promise for designing new proteins to address current problems in a wide range of areas.  I will describe the design of proteins which bind with high affinity and specificity to protein and small molecule targets; such designed high affinity binding proteins could have use as both therapeutics and diagnostics.  I will also describe the design of multicomponent self assembling nanoparticles which could provide the basis for next generation vaccine platforms and targeted delivery vehicles.