Organic Chemistry Seminar

Zoom available upon request.

Nature and synthetic chemists have long recognized the power of the thermodynamic driving force associated with oxidized phosphorous centers to provide stability to biopolymers and drive chemical transformations. Pursuing oxidation pathways that pass through phosphoranyl radicals allows for versatile, controllable and flexible fragmentations to provide access to an array of synthetically useful C- and heteroatom-centered radicals. Our recent efforts in harnessing and controlling the fragmentation of in situ generated phosphoranyl radicals in new reaction development will be presented alongside our combined experimental and computational mechanistic studies leading to next generation reagent design and further advances in synthesis.