Organic Chemistry Seminar

Zoom information available upon request.

My laboratory focuses on applying chemistry-based approaches to propel the development of molecular and cellular modalities for various disorders. I will briefly introduce our efforts in cellular engineering using CRISPR-based technologies and the development of zinc-based prodrug systems, but my presentation will focus on Phosphorylation-Inducing Chimeric Small molecules (PHICS). Small molecules have been classically used to inhibit enzyme function (i.e., loss-of-function), but several new classes of small molecules are emerging that endow neo-functions to enzymes via proximity-mediated effects. I will describe the development and applications of PHICS, which can induce phosphorylation of a given target protein by forcing proximity between a kinase and the target protein.