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Caltech

Organic Chemistry Seminar

Wednesday, October 2, 2024
4:00pm to 5:00pm
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Gates Annex B122
New Tools in the Toolbox for Green & Sustainable Organic Synthesis
Bruce Lipshutz, Professor, Department of Chemistry and Biochemistry, UC Santa Barbara,
  • Internal Event

Several new technologies will be presented, each having been developed in an environmentally responsible fashion. These will include, after some opening remarks, (1) a discussion on new amination reactions of non-PFAS pseudohalides, featuring a very effective, novel, and readily prepared oxidative addition complex (OAC) that leads to couplings in water at low loadings of Pd in minutes; (2) new chemistry in flow, using water, aimed at preparing products from SNAr reactions, and amides, quickly; (3) a new process for effecting Miyaura borylations and notably, their use in a 1-pot sequence involving aromatic/heteroaromatic borylations followed by Suzuki-Miyaura couplings, in 1-pot, and green.

For more information, please contact Annette Luymes by phone at x6016 or by email at [email protected].