Organic Chemistry Seminar
Noyes 153 (J. Holmes Sturdivant Lecture Hall)
Catalytic Synthesis of Tetrasubstituted Carbons Bearing Amines and Heteroaromatics
Catharine H. Larsen,
Assistant Professor of Chemistry,
Department of Chemistry,
University of California, Riverside,
The direct formation of tetrasubstituted carbons bearing amines is rare—especially compared to the wide array of trisubstituted products accessible from multicomponent couplings of aldehydes, amines, and nucleophiles. Dual copper/titanium catalysis is required to overcome the barrier to condensation of a ketone with an amine and subsequent alkynylation, and copper-catalyzed Markovnikov alkyne hydroamination provides a unique alternate pathway to tetrasubstituted propargylamines. In addition, green solvent-free conditions provide one-step syntheses of alkyl- and pyridyl-substituted quinolines.
For more information, please contact Lynne Martinez by phone at 626-395-4004 or by email at [email protected].
Event Series
Organic Chemistry Seminar Series