Organic Chemistry Seminar

It has become increasingly clear that cellular biochemical activities are compartmentalized in nanoscale domains that define the biochemical architecture of the cell.  Despite advances in molecular sensors and optical imaging, direct interrogation of any minute activity domains at the molecular length scale remains a challenge.  In this talk, I will focus on cAMP and Ca²⁺ regulated signaling activities and present studies where we combined genetically encoded fluorescent biosensors, superresolution imaging, targeted biochemical perturbations and mathematic modeling to probe the biochemical activity architecture of the cell.