Special Seminar

Nuclear Magnetic Resonance suffers from low sensitivity for spectroscopy and imaging applications. This sensitivity issue can be solved in certain cases by means of hyperpolarized xenon that is reversibly bound to host structures. Application of saturation transfer pulses allows for further sensitivity enhancement (Hyper-CEST technique). Thus, the host structure has a direct impact on exchange kinetics and the amount of participating xenon. It becomes an important feature to tune the achievable contrast for improved sensitivity and varying levels of specificity for different targeting approaches. This talk will give an overview of the analysis and performance of different host systems with applications in xenon biosensor MRI.